Oral nanotherapeutics with enhanced mucus penetration and ROS-responsive drug release capacities for delivery of curcumin to colitis tissues

Author:

Huang Yamei12345,Canup Brandon S. B.6789,Gou Shuangquan10114512,Chen Nanxi12345,Dai Fangyin12345,Xiao Bo12345ORCID,Li Changming10114512ORCID

Affiliation:

1. State Key Laboratory of Silkworm Genome Biology

2. College of Sericulture

3. Textile and Biomass Sciences

4. Southwest University

5. Chongqing 400715

6. Department of Chemistry

7. Georgia State University

8. Atlanta

9. USA

10. Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing

11. School of Materials and Energy

12. P. R. China

Abstract

Pluronic F127 and catalase facilitated the accumulation and drug release of nanoparticles in colitis tissues, and improved their therapeutic outcomes.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Venture and Innovation Support Program for Chongqing Overseas Returnees

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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