A complex stereochemical relay approach to the antimalarial alkaloid ocimicide A1. Evidence for a structural revision-Reference-Cited by-同舟云学术

A complex stereochemical relay approach to the antimalarial alkaloid ocimicide A1. Evidence for a structural revision

Published:2017 Issue:7 Volume:8 Page:4867-4871
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Nikolayevskiy Herman¹²³⁴^ORCID,Moe Tun Maung Kyaw¹²³⁴,Rablen Paul R.⁵⁶⁷⁴,Ben Mamoun Choukri⁸⁹³⁴,Herzon Seth B.¹²³⁴¹⁰^ORCID

Affiliation:

1. Department of Chemistry

2. Yale University

3. New Haven

4. USA

5. Department of Chemistry and Biochemistry

6. Swarthmore College

7. Swarthmore

8. Department of Internal Medicine

9. Yale School of Medicine

10. Department of Pharmacology

Abstract

The core structure of the potent antimalarial alkaloid ocimicide A₁ was prepared by a complex stereochemical relay. Computational studies suggest a structural revision of the metabolite is necessary.

Funder

National Institutes of Health

Yale University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C7SC01127J

Reference26 articles.

1. Evidence of Artemisinin-Resistant Malaria in Western Cambodia

2. Artemisinin Resistance inPlasmodium falciparumMalaria

3. Synthetic biology’s first malaria drug meets market resistance

4. A Concise Synthesis of (+)-Artemisinin

5. Asymmetric Synthesis of Cyclopropylamine Derivatives

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