Effects of structural modifications on the metal binding, anti-amyloid activity, and cholinesterase inhibitory activity of chalcones
Author:
Affiliation:
1. Department of Pharmaceutical Sciences
2. College of Pharmacy
3. University of Kentucky
4. Lexington
5. USA
6. Department of Cellular and Molecular Biochemistry
7. Center on Aging
Abstract
Twenty chalcone derivatives were synthesized and found to bind Cu2+and Zn2+ions, modulate the dissociation of Aβ aggregates, and inhibit acetylcholinesterase activity. These chalcones show promise for the development of probes and/or therapeutics for Alzheimer's disease.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01478F
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