Thermal stability and conformation of antiparallel duplexes formed by P-stereodefined phosphorothioate DNA/LNA chimeric oligomers with DNA and RNA matrices-Reference-Cited by-同舟云学术

Thermal stability and conformation of antiparallel duplexes formed by P-stereodefined phosphorothioate DNA/LNA chimeric oligomers with DNA and RNA matrices

Published:2015 Issue:39 Volume:13 Page:10032-10040
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Jastrzębska Katarzyna¹²³⁴⁵,Maciaszek Anna¹²³⁴⁵,Dolot Rafał¹²³⁴⁵,Bujacz Grzegorz⁶⁷⁸⁵,Guga Piotr¹²³⁴⁵

Affiliation:

1. Centre of Molecular and Macromolecular Studies

2. Polish Academy of Sciences

3. Department of Bioorganic Chemistry

4. 90-363 Łódź

5. Poland

6. Technical University of Lodz

7. Institute of Technical Biochemistry

8. 90-924 Łódź

Abstract

Oxathiaphospholane derivatives of four LNA-nucleosides were separated into P-diastereomers, and further used in the synthesis of P-stereodefined PS-(DNA/LNA) 11-mers containing 2–3 LNAs.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01474C

Reference35 articles.

1. Phosphorothioate Analogues of Nucleotides?Tools for the Investigation of Biochemical Processes

2. Automated solid-phase synthesis, separation, and stereochemistry of phosphorothioate analogs of oligodeoxyribonucleotides

3. NUCLEOSIDE PHOSPHOROTHIOATES

4. Phosphorothioate Oligodeoxynucleotides: What Is Their Origin and What Is Unique About Them?

5. Two problems in antisense biotechnology: in vitro delivery and the design of antisense experiments

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