Exploiting multivalency and cooperativity of gold nanoparticles for binding phosphatidylinositol (3,4,5)-trisphosphate at sub-nanomolar concentrations-Reference-Cited by-同舟云学术

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Exploiting multivalency and cooperativity of gold nanoparticles for binding phosphatidylinositol (3,4,5)-trisphosphate at sub-nanomolar concentrations

Published:2023 Issue:4 Volume:21 Page:743-747
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

della Sala Flavio¹²^ORCID,Ceresara Elisa¹,Micheli Fabrizio³,Fontana Stefano³,Prins Leonard J.¹^ORCID,Scrimin Paolo¹^ORCID

Affiliation:

1. University of Padova, Department of Chemical Sciences, via Marzolo, 1 35131 Padova, Italy

2. Department of Chemistry, University of Manchester, M13 9LP, UK

3. Aptuit (Verona) Srl, an Evotec company, Campus Levi-Montalcini, Via Alessandro Fleming 4, 37135 Verona, Italy

Abstract

Zn(ii)-functionalized gold nanoparticles selectively bind the lipophilic, polyanionic biomarker PIP3 (orange) vs. hydrophilic ones, such as IP3 (red), with promising application in its extraction from biological fluids.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D2OB02088B

Reference30 articles.

1. Gold Nanoparticles: Assembly, Supramolecular Chemistry, Quantum-Size-Related Properties, and Applications toward Biology, Catalysis, and Nanotechnology

2. Emergence of Complex Chemistry on an Organic Monolayer

3. “Gold rush” in modern science: Fabrication strategies and typical advanced applications of gold nanoparticles in sensing

4. Nanozymes: Gold-Nanoparticle-Based Transphosphorylation Catalysts

5. Nanozymes: A clear definition with fuzzy edges

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