Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods-Reference-Cited by-同舟云学术

Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods

Published:2021 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Klapars Artis¹²³⁴^ORCID,Chung John Y. L.¹²³⁴^ORCID,Limanto John¹²³⁴,Calabria Ralph¹²³⁴,Campeau Louis-Charles¹²³⁴^ORCID,Campos Kevin R.¹²³⁴,Chen Wenyong¹²³⁴,Dalby Stephen M.¹²³⁴,Davis Tyler A.¹²³⁴,DiRocco Daniel A.¹²³⁴,Hyde Alan M.¹²³⁴,Kassim Amude M.¹²³⁴,Larsen Mona Utne¹²³⁴,Liu Guiquan⁵⁶⁷,Maligres Peter E.¹²³⁴,Moment Aaron¹²³⁴,Peng Feng¹²³⁴,Ruck Rebecca T.¹²³⁴^ORCID,Shevlin Michael¹²³⁴,Simmons Bryon L.¹²³⁴,Song Zhiguo Jake¹²³⁴,Tan Lushi¹²³⁴,Wright Timothy J.¹²³⁴,Zultanski Susan L.¹²³⁴^ORCID

Affiliation:

1. Department of Process Research and Development

2. Merck & Co., Inc.

3. Rahway

4. USA

5. WuXi STA

6. Shanghai 200131

7. China

Abstract

An efficient route to the HCV antiviral agent uprifosbuvir was developed in 5 steps from readily available uridine in 50% overall yield.

Publisher

Royal Society of Chemistry (RSC)