VersatileC3-symmetric scaffolds and their use for covalent stabilization of the foldon trimer-Reference-Cited by-同舟云学术

VersatileC3-symmetric scaffolds and their use for covalent stabilization of the foldon trimer

Published:2014 Issue:16 Volume:12 Page:2606-2614
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Berthelmann Arne¹²³,Lach Johannes¹²³,Gräwert Melissa A.⁴⁵⁶⁷⁸,Groll Michael⁴⁵⁶⁷,Eichler Jutta¹²³

Affiliation:

1. Department of Chemistry and Pharmacy

2. University of Erlangen-Nurnberg

3. 91052 Erlangen, Germany

4. Center for Integrated Protein Science at the Department of Chemistry

5. Chair of Biochemistry

6. Technical University of Munich

7. 85747 Munich, Germany

8. European Molecular Biology Laboratory

Abstract

Attachment of foldon monomers to a trimesic acid scaffold enhances thermal stability of the trimer, while maintaining the correct fold.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C3OB42251H

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