Synthesis and in vitro evaluation of tetrahydroisoquinolines with pendent aromatics as sigma-2 (σ2) selective ligands-Reference-Cited by-同舟云学术

Synthesis and in vitro evaluation of tetrahydroisoquinolines with pendent aromatics as sigma-2 (σ2) selective ligands

Published:2014 Issue:5 Volume:12 Page:783-794
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ashford Mark E.¹²³⁴⁵,Nguyen Vu H.¹²³,Greguric Ivan¹²³,Pham Tien Q.¹²³,Keller Paul A.⁴⁵⁶⁷,Katsifis Andrew⁸⁹¹⁰

Affiliation:

1. ANSTO Life Sciences Division

2. ANSTO

3. Kirrawee DC, Australia

4. Centre for Medicinal Chemistry

5. School of Chemistry

6. University of Wollongong

7. , Australia

8. Department of PET and Nuclear Medicine

9. Royal Prince Alfred Hospital

10. Sydney, Australia

Abstract

Sigma-2 selective ligands – a SAR study showing increased potency and selectivity with derivatives showing the potential to be converted into radiolabelled ligands.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C3OB42254B

Reference66 articles.

1. Purification, molecular cloning, and expression of the mammalian sigma1-binding site.

2. sigma receptors. Putative links between nervous, endocrine and immune systems

3. A proposal for the classification of sigma binding sites

4. Rat liver and kidney contain high densities of σ1 and σ2 receptors: characterization by ligand binding and photoaffinity labeling

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