Chemical synthesis and immunological evaluation of cancer vaccines based on ganglioside antigens and α-galactosylceramide

Author:

Romanò Cecilia1ORCID,Jiang Hao1,Tahvili Sahar1,Wei Peng1ORCID,Keiding Ulrik B.1,Clergeaud Gael2,Skovbakke Sarah Line3ORCID,Blomberg Anne Louise3,Hafkenscheid Lise3,Henriksen Jonas R.2ORCID,Andresen Thomas L.2,Goletz Steffen3ORCID,Hansen Anders E.2,Christensen Dennis4,Clausen Mads H.1ORCID

Affiliation:

1. Center for Nanomedicine & Theranostics, Department of Chemistry, Technical University of Denmark, Kemitorvet 207, 2800 Kgs. Lyngby, Denmark

2. Department of Health Technology, Section for Biotherapeutic Engineering and Drug Targeting, Technical University of Denmark, Ørsteds Plads, 2800 Kgs Lyngby, Denmark

3. Department of Biotechnology and Biomedicine, Section for Medical Biotechnology, Biotherapeutic Glycoengineering and Immunology, Technical University of Denmark, Søltofts Plads, 2800 Kgs Lyngby, Denmark

4. Adjuvant Systems Research & Development, Croda Pharma, 2800 Lyngby, Denmark

Abstract

iNKT cells – often referred to as the “Swiss Army knife” of the immune system – have emerged as central players in cancer vaccine therapies.

Funder

China Scholarship Council

Lundbeck Foundation

Novo Nordisk Fonden

European Commission

Danmarks Frie Forskningsfond

Danmarks Tekniske Universitet

Publisher

Royal Society of Chemistry (RSC)

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