Solvent-driven, self-assembled acid-responsive poly(ketalized serine)/siRNA complexes for RNA interference
Author:
Affiliation:
1. Department of Pharmaceutical Sciences
2. School of Pharmacy and Pharmaceutical Sciences
3. University of California
4. Irvine
5. USA
6. Division of Bioengineering
7. Incheon National University
8. Incheon 22012
9. Republic of Korea
Abstract
Self-assembled, biocompatible poly(kSer)/siRNA complexes demonstrate efficient nucleic acid encapsulation, internalization, endosomal escape, and acid-triggered cargo release, tackling multiple hurdles in siRNA delivery.
Funder
National Science Foundation
Publisher
Royal Society of Chemistry (RSC)
Subject
General Materials Science,Biomedical Engineering
Link
http://pubs.rsc.org/en/content/articlepdf/2020/BM/D0BM01478H
Reference50 articles.
1. Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics
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4. Nucleic Acid–Based Therapeutics for Parkinson’s Disease
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