Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils-Reference-Cited by-同舟云学术

Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils

Published:2018 Issue:56 Volume:54 Page:7854-7857
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Brown James W. P.¹²³⁴⁵^ORCID,Meisl Georg¹²³⁴⁵^ORCID,Knowles Tuomas P. J.¹²³⁴⁵^ORCID,Buell Alexander K.⁶⁷⁸⁹^ORCID,Dobson Christopher M.¹²³⁴⁵^ORCID,Galvagnion Céline¹²³⁴⁵^ORCID

Affiliation:

1. Centre for Misfolding Diseases

2. Department of Chemistry

3. University of Cambridge

4. Cambridge CB2 1EW

5. UK

6. University of Düsseldorf

7. Institute of Physical Biology

8. Düsseldorf

9. Germany

Abstract

An increase in temperature allows the conversion of α-synuclein lipid-induced proto-fibrils to mature fibrils by overcoming the associated energy barrier.

Funder

Leverhulme Trust

H2020 Marie Skłodowska-Curie Actions

Sidney Sussex College, University of Cambridge

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC03002B

Reference33 articles.

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4. PROTOFIBRILS, PORES, FIBRILS, AND NEURODEGENERATION: Separating the Responsible Protein Aggregates from The Innocent Bystanders

5. Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

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