Cyclobutane-bearing restricted anchoring residues enabled geometry-specific hydrocarbon peptide stapling-Reference-Cited by-同舟云学术

Cyclobutane-bearing restricted anchoring residues enabled geometry-specific hydrocarbon peptide stapling

Published:2023 Issue:41 Volume:14 Page:11499-11506
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Chen Baobao¹,Liu Chao¹^ORCID,Cong Wei¹,Gao Fei¹^ORCID,Zou Yan²^ORCID,Su Li¹,Liu Lei³^ORCID,Hillisch Alexander⁴⁵,Lehmann Lutz⁴,Bierer Donald⁴,Li Xiang²,Hu Hong-Gang¹^ORCID

Affiliation:

1. School of Medicine or Institute of Translational Medicine, Shanghai University, Shanghai 200444, China

2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China

3. Department of Chemistry, Tsinghua University, Beijing 100084, China

4. Bayer AG, Pharma Division, Drug Discovery Sciences, Aprather Weg 18A, Wuppertal 42096, Germany

5. UCB BioSciences GmbH, Alfred-Nobel-Straße 10, 40789 Monheim am Rhein, Germany

Abstract

Cyclobutane-based conformationally constrained amino acids, termed E7 and Z7, were rationally designed and efficiently synthesized, and were used for RCM-mediated peptide stapling to afford E7-E7 geometry-specific stapled peptides.

Funder

Shanghai Rising-Star Program

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC04279K

Reference51 articles.

1. Towards a proteome-scale map of the human protein–protein interaction network