DNA topoisomerases as additional targets for anticancer monofunctional platinum(ii) complexes-Reference-Cited by-同舟云学术

DNA topoisomerases as additional targets for anticancer monofunctional platinum(ii) complexes

Published:2021 Issue:1 Volume:50 Page:304-310
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Zhang Hongmei¹²³⁴⁵,Yang Tao¹²³⁴⁵,Wang Yanqing⁶⁷⁸⁵,Wang Zenghui⁹¹⁰³⁴⁵,Zhu Zhenzhu¹²³⁴⁵^ORCID,Guo Zijian⁹¹⁰³⁴⁵^ORCID,Wang Xiaoyong¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Pharmaceutical Biotechnology

2. School of Life Sciences

3. Nanjing University

4. Nanjing 210023

5. P. R. China

6. School of Chemical and Environmental Engineering

7. Yancheng Teachers University

8. Yancheng City

9. State Key Laboratory of Coordination Chemistry

10. School of Chemistry and Chemical Engineering

Abstract

Monofunctional platinum(ii) complexes show significant inhibition to DNA topoisomerases I/IIα besides DNA-binding and mitochondrial targeting capabilities, thereby potentiating the cytotoxicity.

Funder

National Natural Science Foundation of China

Nanjing University

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/DT/D0DT02608E

Reference39 articles.

1. Stimuli-Responsive Therapeutic Metallodrugs

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3. Cellular Recognition and Repair of Monofunctional–Intercalative Platinum–DNA Adducts

4. Mechanism of the formation of DNA–protein cross-links by antitumor cisplatin

5. Platinum-Based Drugs and DNA Interactions Studied by Single-Molecule and Bulk Measurements

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