Efficient visible/NIR light-driven uncaging of hydroxylated thiazole orange-based caged compounds in aqueous media

Author:

Hashimoto Ryu1,Minoshima Masafumi1ORCID,Sakata Souhei2,Ono Fumihito2,Ishii Hirokazu3ORCID,Watakabe Yuki3ORCID,Nemoto Tomomi3ORCID,Yanaka Saeko4ORCID,Kato Koichi4ORCID,Kikuchi Kazuya15ORCID

Affiliation:

1. Division of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan

2. Department of Physiology, Faculty of Medicine, Osaka Medical and Pharmaceutical University, 2-7, Daigakucho, Takatsuki, Osaka, 569-8686, Japan

3. Exploratory Research Center on Life and Living Systems (ExCELLS), National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, 444-8787, Japan

4. Exploratory Research Center on Life and Living Systems (ExCELLS), Institute for Molecular Science (IMS), National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, 444-8787, Japan

5. Immunology Frontier Research Center, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan

Abstract

A hydroxylated thiazole orange (HTO)-caged glutamate efficiently releases a glutamate for temporal activation of ion channels under visible-to-NIR light in aqueous media.

Funder

Japan Society for the Promotion of Science

Japan Agency for Medical Research and Development

Naito Foundation

Takeda Science Foundation

Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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