Synthesis of a β-CCT-lanthanide conjugate for binding the dopamine transporter-Reference-Cited by-同舟云学术

Synthesis of a β-CCT-lanthanide conjugate for binding the dopamine transporter

Published:2015 Issue:9 Volume:13 Page:2537-2540
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Naumiec Gregory R.¹²³⁴,Lincourt Grace¹²³⁴,Clever Jeremy P.⁵⁶⁷⁴,McGregor Michael A.¹²³⁴,Kovoor Abraham⁵⁶⁷⁴⁸,DeBoef Brenton¹²³⁴

Affiliation:

1. Department of Chemistry

2. University of Rhode Island

3. Kingston

4. USA

5. Kovogen

6. LLC

7. Mystic

8. Department of Biomedical and Pharmaceutical Sciences

Abstract

The development of a β-CCT-lanthanide conjugate that binds the dopamine transporter (DAT) with high affinity (K_d = 303 nM) is described. This molecular probe could be used for in vivo or in vitro studies of the DAT via MRI, PET or SPECT.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02165G

Reference32 articles.

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