Exploring the conformational dynamics of the SARS-CoV-2 SL4 hairpin by combining optical tweezers and base analogues-Reference-Cited by-同舟云学术

Exploring the conformational dynamics of the SARS-CoV-2 SL4 hairpin by combining optical tweezers and base analogues

Published:2024 Issue:2 Volume:16 Page:752-764
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Sundar Rajan Vinoth¹²^ORCID,Wypijewska del Nogal Anna²^ORCID,Levin Sune¹,Wilhelmsson L. Marcus²^ORCID,Westerlund Fredrik¹^ORCID

Affiliation:

1. Division of Chemical Biology, Department of Life Sciences, Chalmers University of Technology, Gothenburg, SE-412 96, Sweden

2. Division of Chemistry and Biochemistry, Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, SE-412 96, Sweden

Abstract

We characterize the stability, conformational dynamics, (un)folding pathways, as well as identify a promising drug–target site within the SL4 hairpin of the SARS-CoV-2 by combining base analogues and optical tweezers.

Funder

Chalmers Tekniska Högskola

H2020 European Research Council

Stiftelsen för Strategisk Forskning

Vetenskapsrådet

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NR/D3NR04110G

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