Harpagide, a natural product, promotes synaptic vesicle release as measured by nanoelectrode amperometry-Reference-Cited by-同舟云学术

Harpagide, a natural product, promotes synaptic vesicle release as measured by nanoelectrode amperometry

Published:2020 Issue:3 Volume:11 Page:778-785
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Tang Yun¹²³⁴⁵,Yang Xiao-Ke¹²³⁴⁵,Zhang Xin-Wei¹²³⁴⁵,Wu Wen-Tao¹²³⁴⁵,Zhang Fu-Li¹²³⁴⁵,Jiang Hong¹²³⁴⁵,Liu Yan-Ling¹²³⁴⁵,Amatore Christian⁶⁷⁸⁹⁵,Huang Wei-Hua¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education)

2. College of Chemistry and Molecular Sciences

3. Wuhan University

4. Wuhan 430072

5. China

6. State Key Laboratory of Physical Chemistry of Solid Surfaces

7. College of Chemistry and Chemical Engineering

8. Xiamen University

9. Xiamen

Abstract

Nanoelectrode amperometry was used to monitor DA release inside single DAergic synapses, and demonstrated that harpagide effectively enhances synaptic DA release by reducing intracellular ROS generation and inhibiting α-Syn phosphorylation.

Funder

National Natural Science Foundation of China

Xiamen University

Université de Recherche Paris Sciences et Lettres

École Normale Supérieure

Centre National de la Recherche Scientifique

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/C9SC05538J