Recombinant silk fibroin incorporated cell-adhesive sequences produced by transgenic silkworm as a possible candidate for use in vascular graft

Author:

Asakura Tetsuo123,Isozaki Makoto123,Saotome Toshiki123,Tatematsu Ken-ichiro456,Sezutsu Hideki456,Kuwabara Nobuo78,Nakazawa Yasumoto123

Affiliation:

1. Department of Biotechnology

2. Tokyo University of Agriculture and Technology

3. Koganei, Japan

4. Transgenic Silkworm Research Unit

5. National Institute of Agrobiological Sciences

6. Tsukuba, Japan

7. Gunma Sericultural Technology Center

8. Maebashi, Japan

Abstract

Transgenic silk fibroins that incorporated the laminin sequence were prepared. The adhesive activities tend to increase in the TG silk fibroins relative to WT silk fibroins.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Reference43 articles.

1. Tissue engineering of blood vessels

2. Polyhedral oligomeric silsequioxane–polyurethane nanocomposite microvessels for an artificial capillary bed

3. Silk fibroin microtubes for blood vessel engineering

4. T. Asakura and D. L.Kaplan, Silk Production and Processing, in Encyclopedia of Agricultural Science, ed. J. A. Arutzen, Academic Press, NY, 1994, vol. 4, pp. 1–11

5. Animal silks: their structures, properties and artificial production

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