Novel indolyl 1,2,4-triazole derivatives as potential anti-proliferative agents: <i>in silico</i> studies, synthesis, and biological evaluation-Reference-Cited by-同舟云学术

Novel indolyl 1,2,4-triazole derivatives as potential anti-proliferative agents: in silico studies, synthesis, and biological evaluation

Published:2024 Issue:1 Volume:15 Page:293-308
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Ghobish Sarah A.¹^ORCID,Mohamed Khaled O.²³,Farag Nahla¹^ORCID,Farag Doaa B.¹^ORCID

Affiliation:

1. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt

2. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

3. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Sinai University (Arish branch), El Arish, Egypt

Abstract

A new series of indolyl 1,2,4-triazole scaffolds was designed, synthesised, and biologically evaluated for their inhibitory activity against both CDK4 and CDK6.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00524K

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