Copper-catalyzed gem-difluoromethylenation of C(sp2)–H bonds of alkenes-Reference-Cited by-同舟云学术

Copper-catalyzed gem-difluoromethylenation of C(sp2)–H bonds of alkenes

Published:2017 Issue:7 Volume:4 Page:1239-1243
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Xu Hui¹²³⁴⁵,Wang Dejing¹²³⁴⁵,Chen Yunrong¹²³⁴⁵,Wan Wen¹²³⁴⁵,Deng Hongmei⁶³⁴⁵,Ma Kesen⁷⁸⁹¹⁰¹¹,Wu Shaoxiong¹²¹³¹⁴¹⁵,Hao Jian¹²³⁴⁵,Jiang Haizhen¹²³⁴⁵

Affiliation:

1. Department of Chemistry

2. Innovative Drug Research Center

3. Shanghai University

4. Shanghai

5. P. R. China

6. Laboratory for Microstructures

7. Department of Biology

8. University of Waterloo

9. 200 University Avenue West

10. Waterloo

11. Canada

12. Emory NMR Research Center

13. Emory University

14. Atlanta

15. USA

Abstract

Copper-catalyzed gem-difluoromethylenation of the C(sp²)–H bonds of alkenes has been developed. This protocol is the first to efficiently achieve gem-difluoromethylenation of C(sp²)–H bonds of unactivated aliphatic terminal olefins and is applied in gem-difluoromethylenation/cyclization of alkenes.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/QO/C7QO00119C

Reference63 articles.

1. Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments

2. Understanding organofluorine chemistry. An introduction to the C–F bond

3. Evidence That Histidine Protonation of Receptor-Bound Anthrax Protective Antigen Is a Trigger for Pore Formation

4. Novel Method for Incorporating the CHF2 Group into Organic Molecules Using BrF3

5. Reversal of stereoselectivity in the Evans aldol reaction of α,α-difluoro and α,α,α-trifluoro carbonyl compounds

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