Engineering lanmodulin's selectivity for actinides over lanthanides by controlling solvent coordination and second-sphere interactions-Reference-Cited by-同舟云学术

Engineering lanmodulin's selectivity for actinides over lanthanides by controlling solvent coordination and second-sphere interactions

Published:2022 Issue:20 Volume:13 Page:6054-6066
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Mattocks Joseph A.¹^ORCID,Cotruvo Joseph A.¹^ORCID,Deblonde Gauthier J.-P.²³^ORCID

Affiliation:

1. Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA

2. Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, California 94550, USA

3. Glenn T. Seaborg Institute, Lawrence Livermore National Laboratory, Livermore, California 94550, USA

Abstract

Nature’s most potent protein for f-elements, lanmodulin, relies on subtle first-sphere/second-sphere interactions to bind metal ions. Dissecting lanmodulin’s binding mechanism yielded variants with enhanced actinide/lanthanide selectivity.

Funder

U.S. Department of Energy

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC01261H

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