Long-term delivery of rhIGF-1 from biodegradable poly(lactic acid)/hydroxyapatite@Eudragit double-layer microspheres for prevention of bone loss and articular degeneration in C57BL/6 mice-Reference-Cited by-同舟云学术

Long-term delivery of rhIGF-1 from biodegradable poly(lactic acid)/hydroxyapatite@Eudragit double-layer microspheres for prevention of bone loss and articular degeneration in C57BL/6 mice

Published:2018 Issue:19 Volume:6 Page:3085-3095
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Liu Rui¹²³⁴⁵,Chen Yan⁶²³⁴⁵^ORCID,Liu Lanlan⁷⁸⁹¹⁰,Gong Yong¹²³⁴⁵,Wang Mingbo⁷⁸⁹¹⁰,Li Songjian¹²³⁴⁵^ORCID,Chen Changsheng⁷⁸⁹¹⁰,Yu Bo¹²³⁴⁵^ORCID

Affiliation:

1. Department of Orthopedics

2. Zhujiang Hospital

3. Southern Medical University

4. Guangzhou 510282

5. China

6. Department of Ultrasonic Diagnosis

7. Key Laboratory of Biomedical Materials and Implant Devices

8. Research Institute of Tsinghua University in Shenzhen

9. Shenzhen 518057

10. P. R. China

Abstract

Insulin-like growth factor (IGF-1) has encouraged researchers to investigate its various potential therapeutic uses such as in the treatment of osteoporosis and repair of articular cartilage.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Guangdong Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2018/TB/C8TB00324F

Reference45 articles.

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2. Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models