Peptide conjugates with polyaromatic hydrocarbons can benefit the activity of catalytic RNAs-Reference-Cited by-同舟云学术

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Peptide conjugates with polyaromatic hydrocarbons can benefit the activity of catalytic RNAs

Published:2023 Issue:37 Volume:14 Page:10318-10328
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Sweeney Kevin J.¹,Le Tommy¹,Jorge Micaella Z.²^ORCID,Schellinger Joan G.²,Leman Luke J.³^ORCID,Müller Ulrich F.¹^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093, USA

2. Department of Chemistry & Biochemistry, University of San Diego, San Diego, CA 92110, USA

3. Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA

Abstract

The study identified a catalytic RNA (ribozyme) that shows a 900-fold activity increase in the presence of a polyaromatic hydrocarbon – peptide conjugate. Similar conjugates may have aided the emergence of an RNA world.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC03540A

Reference66 articles.

1. A.Rich , Horizons in Biochemistry , New York, NY , 1962 , pp. 103–126

2. C. R.Woese , The molcular basis for genetic expression , Harper & Row , New York , 1967

3. The origin of the genetic code

4. Evolution of the genetic apparatus

5. Origin of life: The RNA world

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