Decorin in the spatial control of collagen mineralization

Author:

Bai Yuming123,Wu Peng123,Zhang Qiufang123,Lin Feng123,Hu Ling4,Zhang Zhisheng123,Huang Wenxia123,Xiao Yin56,Zuo Qiliang123ORCID

Affiliation:

1. Stomatological Hospital of Xiamen Medical College, Xiamen Medical College, Xiamen, PR China

2. Xiamen Key Laboratory of Stomatological Disease Diagnosis and Treatment, Xiamen, PR China

3. Engineering Research Center of Fujian University for Stomatological Biomaterials, Xiamen, PR China

4. Department of Pharmacy and Pharmaceutical Sciences, Xiamen Medical College, Xiamen, PR China

5. School of Medicine and Dentistry, Griffith University, Gold Coast, Australia

6. Australia-China Centre for Tissue Engineering and Regenerative Medicine, Brisbane, Australia

Abstract

Both COL I and pCOL I fibrils undergo nonhierarchical and hierarchical intrafibrillar mineralization in the PLIP system, respectively. However, DCN disrupts the mineralization process, indicating the inhibition of DCN in collagen mineralization.

Funder

National Natural Science Foundation of China

Fujian Provincial Health Commission

Publisher

Royal Society of Chemistry (RSC)

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