Glibenclamide–sulfonylurea receptor 1 antagonist alleviates LPS-induced BV2 cell activation through the p38/MAPK pathway-Reference-Cited by-同舟云学术

Glibenclamide–sulfonylurea receptor 1 antagonist alleviates LPS-induced BV2 cell activation through the p38/MAPK pathway

Published:2017 Issue:44 Volume:7 Page:27206-27213
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Xu Zhiming¹²³⁴^ORCID,Liu Yingliang¹²³⁴,Yang Dianxu¹²³⁴,Yuan Fang¹²³⁴,Ding Jun¹²³⁴,Wang Liping⁵⁶⁷³⁴,Qu Meijie⁵⁶⁷³⁴,Yang Guoyuan⁵⁶⁷³⁴,Tian Hengli¹²³⁴

Affiliation:

1. Department of Neurosurgery

2. Shanghai Jiao Tong University Affiliated Sixth People's Hospital

3. Shanghai

4. China

5. Department of Neurology

6. Ruijin Hospital

7. Shanghai Jiao Tong University School of Medicine

Abstract

We investigated the anti-neuroinflammatory activity and mechanism of glibenclamide, sulfonylurea receptor 1 (Sur1) antagonist, against LPS-induced microglial activationin vitro.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA03042H

Reference54 articles.

1. ATP-SENSITIVE POTASSIUM CHANNELS: A Model of Heteromultimeric Potassium Channel/Receptor Assemblies

2. ABCC8 and ABCC9: ABC transporters that regulate K+ channels

3. Newly expressed SUR1-regulated NCCa-ATP channel mediates cerebral edema after ischemic stroke

4. Glibenclamide Reduces Inflammation, Vasogenic Edema, and Caspase-3 Activation after Subarachnoid Hemorrhage

5. Endothelial sulfonylurea receptor 1–regulated NCCa-ATP channels mediate progressive hemorrhagic necrosis following spinal cord injury

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