Engineering a dual-responsive, exosome-surface anchored DNA nanosensor for microenvironment monitoring <i>in vivo</i>-Reference-Cited by-同舟云学术

Engineering a dual-responsive, exosome-surface anchored DNA nanosensor for microenvironment monitoring in vivo

Published:2022 Issue:22 Volume:58 Page:3661-3664
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Yu Dingwen¹,Yang Jinfeng²,Wang Lijuan²,Chen Mingjian³,Yang Ronghua¹^ORCID,Zheng Jing¹^ORCID

Affiliation:

1. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Institute of Chemical Biology and Nanomedicine (ICBN), Hunan University, Changsha, 410082, China

2. Department of Anesthesiology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, China

3. Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medical Science, Central South University, Changsha, 410083, China

Abstract

We propose an azoreductase and pH dual-responsive amphiphilic pyramidal tetrahedral DNA probe to construct a circulating exosome-surface anchored nanosensor for monitoring of microenvironment in vivo.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D1CC07070C

Reference17 articles.

1. Exosomes: composition, biogenesis and function

2. Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

3. Reassessment of Exosome Composition

4. Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment

5. Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

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