Single-cell RNA-sequencing of migratory breast cancer cells: discovering genes associated with cancer metastasis-Reference-Cited by-同舟云学术

Single-cell RNA-sequencing of migratory breast cancer cells: discovering genes associated with cancer metastasis

Published:2019 Issue:24 Volume:144 Page:7296-7309
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Chen Yu-Chih¹²³⁴⁵^ORCID,Sahoo Saswat⁶²³⁴,Brien Riley¹²³⁴,Jung Seungwon¹²³⁴,Humphries Brock⁷⁸²³⁴,Lee Woncheol¹²³⁴,Cheng Yu-Heng¹²³⁴,Zhang Zhixiong¹²³⁴^ORCID,Luker Kathryn E.⁷⁸²³⁴,Wicha Max S.⁵²³⁴,Luker Gary D.⁶²³⁴⁷,Yoon Euisik¹²³⁴⁶

Affiliation:

1. Department of Electrical Engineering and Computer Science

2. University of Michigan

3. Ann Arbor

4. USA

5. Forbes Institute for Cancer Discovery

6. Department of Biomedical Engineering

7. Center for Molecular Imaging

8. Department of Radiology

Abstract

We enriched migratory breast cancer cells with enhanced tumor formation and metastasis capability using microfluidics and performed single-cell RNA-sequencing to identify unique EMT and CSC signature of migratory cells.

Funder

National Cancer Institute

University of Michigan

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/AN/C9AN01358J

Reference49 articles.

1. Hallmarks of Cancer: The Next Generation

2. Tumor metastasis: mechanistic insights and clinical challenges