Different molecular recognition by three domains of the full-length GRB2 to SOS1 proline-rich motifs and EGFR phosphorylated sites

Author:

Tateno Keita1ORCID,Ando Takami1ORCID,Tabata Maako1ORCID,Sugasawa Haruka1ORCID,Hayashi Toshifumi1ORCID,Yu Sangya1ORCID,PM Sayeesh1ORCID,Inomata Kohsuke1ORCID,Mikawa Tsutomu12ORCID,Ito Yutaka1ORCID,Ikeya Teppei1ORCID

Affiliation:

1. Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, 1-1 Minamiosawa, Hachioji, Tokyo 192-0397, Japan

2. RIKEN Center for Biosystems Dynamics Research, RIKEN, 1-7-22 Suehiro-Cho, Tsurumi-Ku, Yokohama 230-0045, Japan

Abstract

The asymmetric physical properties of the two SH3 domains of GRB2, including dynamics and binding affinities, may contribute to the formation of liquid–liquid phase separation.

Funder

Core Research for Evolutional Science and Technology

Japan Science and Technology Agency

Japan Society for the Promotion of Science

Precise Measurement Technology Promotion Foundation

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Royal Society of Chemistry (RSC)

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