Antitubercular evaluation of dihydropyridine–triazole conjugates: design, synthesis, <i>in vitro</i> screening, SAR and <i>in silico</i> ADME predictions-Reference-Cited by-同舟云学术

Antitubercular evaluation of dihydropyridine–triazole conjugates: design, synthesis, in vitro screening, SAR and in silico ADME predictions

Published:2024 Issue:8 Volume:15 Page:2867-2881
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Kushawaha Ajay Kishor¹,Jaiswal Arvind Kumar¹,Gupta Jay¹,Katiyar Sarita¹²,Ansari Alisha¹²,Bhatt Hemlata¹²,Sharma Sandeep K.³,Choudhury Abhijit Deb⁴,Bhatta Rabi Sankar⁴²^ORCID,Singh Bhupendra N.³²,Sashidhara Koneni V.¹⁵²^ORCID

Affiliation:

1. Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, BS 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India

2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, U.P, India

3. Molecular Microbiology & Immunology (MMI) Division, CSIR-Central Drug Research Institute, BS 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India

4. Pharmaceutics and Pharmacokinetics Division, CSIR- Central Drug Research Institute, Lucknow, India

5. Sophisticated Analytical Instrument Facility & Research, CSIR-Central Drug Research Institute, BS-10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, U.P, India

Abstract

The synthesis of a novel series of 32 dihydropyridine–triazole conjugates using click chemistry and their antitubercular activity, structure–activity relationship (SAR) analysis, and ADME predictions are discussed.

Funder

University Grants Commission

Department of Science and Technology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00377B

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