Design, synthesis, and anticancer evaluation of novel coumarin/thiazole congeners as potential CDK2 inhibitors with molecular dynamics-Reference-Cited by-同舟云学术

Design, synthesis, and anticancer evaluation of novel coumarin/thiazole congeners as potential CDK2 inhibitors with molecular dynamics

Published:2024 Issue:27 Volume:14 Page:18838-18855
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Bondock Samir¹^ORCID,Alabbad Nada¹,Hossan Aisha¹,Abdou Moaz M.²^ORCID,Shati Ali A.³,Alfaifi Mohammad Y.³,Elbehairi Serag E. I.³,Mohamed Nada M.⁴^ORCID

Affiliation:

1. Chemistry Department, Faculty of Science, King Khalid University, 9004 Abha, Saudi Arabia

2. Egyptian Petroleum Research Institute, Nasr City, 11727, Cairo, Egypt

3. Biology Department, Faculty of Science, King Khalid University, 9004 Abha, Saudi Arabia

4. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Modern University for Technology and Information, MTI, Cairo, Egypt

Abstract

A series of novel coumarin–thiazoles was designed and synthesized as a possible CDK2 inhibitor with anticancer activity with low toxicity.

Funder

King Khalid University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA02456G

Reference55 articles.

1. Cyclin-dependent kinase 2 (CDK2) inhibitors and others novel CDK inhibitors (CDKi) in breast cancer: clinical trials, current impact, and future directions

2. The Rb-CDK4/6 Signaling Pathway Is Critical in Neural Precursor Cell Cycle Regulation

3. p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells

4. Cyclin-Dependent Kinase-2 as a Target for Cancer Therapy: Progress in the Development of CDK2 Inhibitors as Anti-Cancer Agents

5. Cyclin-Dependent Kinase 2 Inhibitors in Cancer Therapy: An Update

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The current landscape of coumarin hybrids with antibreast cancer therapeutic applications: An updated review;Archiv der Pharmazie;2024-07-09