α-Conotoxin GI triazole-peptidomimetics: potent and stable blockers of a human acetylcholine receptor-Reference-Cited by-同舟云学术

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α-Conotoxin GI triazole-peptidomimetics: potent and stable blockers of a human acetylcholine receptor

Published:2019 Issue:6 Volume:10 Page:1671-1676
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Knuhtsen Astrid¹²³⁴^ORCID,Whitmore Charlotte⁵⁶⁷⁸,McWhinnie Fergus S.¹²³⁴^ORCID,McDougall Laura¹²³⁴,Whiting Rachel⁵⁶⁷⁸,Smith Brian O.⁹¹⁰²³⁴^ORCID,Timperley Christopher M.⁵⁶⁷⁸^ORCID,Green A. Christopher⁵⁶⁷⁸,Kinnear Kenneth I.⁵⁶⁷⁸,Jamieson Andrew G.¹²³⁴^ORCID

Affiliation:

1. School of Chemistry

2. University of Glasgow

3. Glasgow

4. G12 8QQ UK

5. Chemical, Biological and Radiological Division

6. Defence Science and Technology Laboratory

7. Salisbury

8. SP4 0JQ UK

9. Institute of Molecular, Cell & Systems Biology

10. College of Medical, Veterinary & Life Sciences

Abstract

A conotoxin peptidomimetic was developed as a potential muscle relaxant that is highly potent and blood plasma stable.

Funder

Engineering and Physical Sciences Research Council

Defence Science and Technology Laboratory

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C8SC04198A

Reference34 articles.

1. Discovery, Synthesis, and Structure–Activity Relationships of Conotoxins

2. Enhancing the therapeutic potential of peptide toxins

3. Progress and challenges in the optimization of toxin peptides for development as pain therapeutics

4. Peptides isolated from the venom of Conus geographus block neuromuscular transmission

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4. Discovery and optimisation of conotoxin Vc1.1 and analogues with analgesic properties;Australian Journal of Chemistry;2023-10-06

5. Development of an o-aminoanilide-mediated native chemical ligation-assisted DADA strategy for the synthesis of disulfide surrogate peptides;Organic & Biomolecular Chemistry;2023

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