Polarisation effects on the H-bond acceptor properties of secondary amides-Reference-Cited by-同舟云学术

Polarisation effects on the H-bond acceptor properties of secondary amides

Published:2023 Issue:40 Volume:14 Page:11151-11157
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Hanna Fergal E.¹^ORCID,Root Alexander J.¹^ORCID,Hunter Christopher A.¹^ORCID

Affiliation:

1. Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK

Abstract

An intramolecular H-bond between a pyridine and an amide NH group increases the H-bond acceptor strength of the amide carbonyl oxygen. Polarisation of the amide group is directly proportional to the polarity of the pyridine H-bond acceptor.

Funder

AstraZeneca

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC03823H

Reference27 articles.

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4. Quantifying Intermolecular Interactions: Guidelines for the Molecular Recognition Toolbox

5. Cooperative effect in hydrogen bonding of N-methylacetamide in carbon tetrachloride solution confirmed by NMR and IR spectroscopies

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