Synthesis, antitumor activity, 3D-QSAR and molecular docking studies of new iodinated 4-(3<i>H</i>)-quinazolinones 3<i>N</i>-substituted-Reference-Cited by-同舟云学术

Synthesis, antitumor activity, 3D-QSAR and molecular docking studies of new iodinated 4-(3H)-quinazolinones 3N-substituted

Published:2022 Issue:33 Volume:12 Page:21340-21352
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Pérez-Fehrmann Marcia¹^ORCID,Kesternich Víctor¹^ORCID,Puelles Arturo¹,Quezada Víctor¹^ORCID,Salazar Fernanda¹,Christen Philippe²³^ORCID,Castillo Jonathan⁴,Cárcamo Juan Guillermo⁴⁵,Castro-Alvarez Alejandro⁶⁷^ORCID,Nelson Ronald¹^ORCID

Affiliation:

1. Departamento de Química, Facultad de Ciencias, Universidad Católica del Norte, Av. Angamos 0610, Antofagasta 1270709, Chile

2. School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva 4, Switzerland

3. Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, 1211 Geneva 4, Switzerland

4. Instituto de Bioquímica y Microbiología, Facultad de Ciencias, Universidad Austral de Chile, Campus Isla Teja, Valdivia, Chile

5. Centro FONDAP, Interdisciplinary Center for Aquaculture Research (INCAR), Chile

6. Laboratorio de Bioproductos Farmacéuticos y Cosméticos, Centro de Excelencia en Medicina Traslacional, Facultad de Medicina, Universidad de La Frontera, Av. Francisco Salazar 01145, Temuco, 4780000, Chile

7. Departamento de Química de los Materiales, Facultad de Química y Biología, Universidad de Santiago de Chile, Casilla 40, Correo 33, Santiago, Chile

Abstract

New iodinated 4-(3H)-quinazolinones 3N-substituted with antitumor activity and 3D-QSAR and molecular docking studies as dihydrofolate reductase (DHFR) inhibitors.

Funder

Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias

European Commission

Fondo Nacional de Desarrollo Científico y Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA03684C

Reference121 articles.

1. Pharmaceutical prospects of naturally occurring quinazolinone and its derivatives

2. New Azole Antifungals. 3. Synthesis and Antifungal Activity of 3-Substituted-4(3H)-quinazolinones

3. Quinazolines and quinazolinones as ubiquitous structural fragments in medicinal chemistry: An update on the development of synthetic methods and pharmacological diversification

4. Recent advances in the structural library of functionalized quinazoline and quinazolinone scaffolds: Synthetic approaches and multifarious applications

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