Novel diamine-scaffold based <i>N</i>-acetylgalactosamine (GalNAc)–siRNA conjugate: synthesis and <i>in vivo</i> activities-Reference-Cited by-同舟云学术

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Novel diamine-scaffold based N-acetylgalactosamine (GalNAc)–siRNA conjugate: synthesis and in vivo activities

Published:2024 Issue:25 Volume:14 Page:17461-17466
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Li Qiang¹²^ORCID,Dong Mingxin¹^ORCID,Chen Pu²³^ORCID

Affiliation:

1. Department of Medicinal Chemistry, School of Pharmacy, Qingdao University, Qingdao 266021, China

2. Research and Development Department, NanoPeptide (Qingdao) Biotechnology Ltd, Qingdao, China

3. Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON, Canada

Abstract

GalNAc-conjugated siRNA has shown remarkable potential in liver-targeted delivery in recent years.

Funder

Shandong Provincial Postdoctoral Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA03023K

Reference32 articles.

1. Tapping the RNA world for therapeutics

2. Antisense technology: an overview and prospectus

3. Therapeutic siRNA: state of the art

4. mRNA: Vaccine or Gene Therapy? The Safety Regulatory Issues

5. Aptamer-based targeted therapy

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