Fibromodulin facilitates the osteogenic effect of Masquelet's induced membrane by inhibiting the TGF-β/SMAD signaling pathway-Reference-Cited by-同舟云学术

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Fibromodulin facilitates the osteogenic effect of Masquelet's induced membrane by inhibiting the TGF-β/SMAD signaling pathway

Published:2024 Issue:7 Volume:12 Page:1898-1913
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Wang Kai¹²^ORCID,Zhou Ming¹²,Zhang Yuanshu¹,Jin Yesheng²,Xue Yuan¹,Mao Dong³,Rui Yongjun¹

Affiliation:

1. Department of Orthopedics, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, 214062, China

2. Suzhou Medical College of Soochow University, Suzhou, 215031, China

3. Orthopaedic Institute, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, 214062, China

Abstract

Schematic illustration of the mechanism by which an IM promotes bone formation. FMOD secreted by the IM promotes osteogenesis of BMSCs and angiogenesis of HUVECs by inhibiting the TGF-β/SMAD signaling pathway, thus facilitating bone formation.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/BM/D3BM01665J

Reference53 articles.

1. Treatment of non-unions with bone defects: Which option and why?

2. Influence of the induced membrane filled with syngeneic bone and regenerative cells on bone healing in a critical size defect model of the rat’s femur

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