FGF-2 induces a failure of cell cycle progression in cells harboring amplified K-Ras, revealing new insights into oncogene-induced senescence-Reference-Cited by-同舟云学术

FGF-2 induces a failure of cell cycle progression in cells harboring amplified K-Ras, revealing new insights into oncogene-induced senescence

Published:2021 Issue:5 Volume:17 Page:725-739
ISSN:2515-4184
Container-title:Molecular Omics
language:en
Short-container-title:Mol. Omics

Author:

Lund Peder J.¹^ORCID,Lopes Mariana¹²^ORCID,Sidoli Simone¹^ORCID,Coradin Mariel¹³^ORCID,Vitorino Francisca Nathália de Luna²^ORCID,da Cunha Julia Pinheiro Chagas²^ORCID,Garcia Benjamin A.¹

Affiliation:

1. Department of Biochemistry and Biophysics, Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

2. Laboratório de Ciclo Celular, Center of Toxins, Immune Response and Cell Signaling – CeTICS, Instituto Butantan, São Paulo 05503-900, Brazil

3. Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

Abstract

Cells harboring oncogenic Ras were profiled with multi-omics to understand why they senesce instead of proliferate in response to growth factor signaling.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Crohn's and Colitis Foundation of America

National Institutes of Health

Leukemia Research Foundation

American Federation for Aging Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MO/D1MO00019E