Spatiotemporal tracking of the transport of RNA nano-drugs: from transmembrane to intracellular delivery

Author:

Pang Xuelei1,Zhang Qingrong1,Li Siying1,Zhao Jing1,Cai Mingjun2ORCID,Wang Hongda2ORCID,Xu Haijiao2,Yang Guocheng1,Shan Yuping1ORCID

Affiliation:

1. School of Chemistry and Life Science, Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, China

2. Changchun Institute of Applied Chemistry, State Key Laboratory of Electroanalytical Chemistry, Chinese Academy of Science, Changchun 130022, China

Abstract

This report proposes the transport dynamic mechanism of targeted RNA nano-drugs from extracellular to intracellular under physiological conditions. The dynamic process of RNA nano-drug entry into cells is analyzed at the single particle level.

Funder

Outstanding Young Talent Foundation of Jilin Province

Education Department of Jilin Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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