Naphthoquinone–dopamine hybrids disrupt α-synuclein fibrils by their intramolecular synergistic interactions with fibrils and display a better effect on fibril disruption

Author:

Zhou Yun1ORCID,Yao Yifei1,Yang Zhongyuan1,Tang Yiming1,Wei Guanghong1ORCID

Affiliation:

1. Department of Physics, State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Sciences (Ministry of Education), Fudan University, Shanghai 200438, People's Republic of China

Abstract

NQDA destabilizes αSyn fibrils through synergistic π–π stacking and cation-π interactions.

Funder

Natural Science Foundation of Shanghai

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

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