Glycosylated platinum(iv) prodrugs demonstrated significant therapeutic efficacy in cancer cells and minimized side-effects-Reference-Cited by-同舟云学术

Glycosylated platinum(iv) prodrugs demonstrated significant therapeutic efficacy in cancer cells and minimized side-effects

Published:2016 Issue:29 Volume:45 Page:11830-11838
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Ma Jing¹²³⁴⁵,Wang Qingpeng¹²³⁴⁵,Yang Xiande¹²³⁴⁵,Hao Wenpei¹²³⁴⁵,Huang Zhonglv¹²³⁴⁵,Zhang Jiabao¹²³⁴⁵,Wang Xin¹²³⁴⁵,Wang Peng George¹²³⁴⁵

Affiliation:

1. College of Pharmacy

2. State Key Laboratory of Elemento-organic Chemistry

3. Nankai University

4. Tianjin 300071

5. P. R. China

Abstract

Conjugates (A1–A5) of the Pt(iv) derivative (A6) with amino groups from peracetyl glucose, rhamnose and mannose with a propyl amino or ethyl amino linker at the reducing end were synthesized and exhibited significant therapeutic efficacy in tumour cells, especially for prostate cancer (PCa).

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/DT/C6DT02207C

Reference49 articles.

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