A synergistic therapeutic nano-eyedrop for dry eye disease based on ascorbic acid-coupled exosomes-Reference-Cited by-同舟云学术

A synergistic therapeutic nano-eyedrop for dry eye disease based on ascorbic acid-coupled exosomes

Published:2023 Issue:4 Volume:15 Page:1890-1899
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Ma Fang¹²,Feng Jing¹²,Liu Xi³,Tian Ying¹²,Wang Wen-Jing⁴²,Luan Fu-Xiao¹²,Wang Ying-Jie¹²,Yang Wei-Qiang¹²,Bai Jing-Yi¹⁵,Zhang Yi-Quan¹²,Tao Yong¹^ORCID

Affiliation:

1. Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P. R. China

2. Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, P. R. China

3. Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department and 4th Medical Center, PLA General Hospital and PLA Medical College, Beijing 100048, P. R. China

4. Department of Neurosurgery, Health Science Center, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen 518035, P. R. China

5. Department of Ophthalmology, Beijing Huairou Hospital, Capital Medical University, Beijing 101400, P.R. China

Abstract

The advanced eyedrop, mExo@AA was synthesized by reducing gold nanoparticles onto the exosomal phospholipid membrane in situ using AA. In the BAC-induced mice model, mExo@AA demonstrated superior damage repair, ROS scavenging, and anti-inflammation.

Funder

Basic and Applied Basic Research Foundation of Guangdong Province

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NR/D2NR05178H

Reference40 articles.

1. The Epidemiology of Dry Eye Disease: Report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007)