Rapid microfluidic platform for screening and enrichment of cells secreting virus neutralizing antibodies-Reference-Cited by-同舟云学术

Rapid microfluidic platform for screening and enrichment of cells secreting virus neutralizing antibodies

Published:2022 Issue:13 Volume:22 Page:2578-2589
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Lin Weikang Nicholas¹,Tay Matthew Zirui²,Wong Joel Xu En²,Lee Chia Yin³,Fong Siew-Wai²,Wang Cheng-I³,Ng Lisa Fong Poh²⁴⁵⁶,Renia Laurent²⁷⁸,Chen Chia-Hung⁸^ORCID,Cheow Lih Feng¹⁹¹⁰^ORCID

Affiliation:

1. Department of Biomedical Engineering, National University of Singapore, Singapore

2. A*STAR Infectious Diseases Labs, Agency for Science, Technology and Research (A*STAR), Singapore

3. Singapore Immunology Network, A*STAR, Singapore

4. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

5. National Institute of Health Research, Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, UK

6. Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK

7. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore

8. School of Biological Sciences, Nanyang Technological University, Singapore

9. Department of Biomedical Engineering, City University of Hong Kong, Hong Kong

10. Institute for Health Innovation & Technology (iHealthtech), Singapore

Abstract

Drop-PEARL enables rapid screening and isolation of virus-neutralizing antibody secreting cells for high-throughput therapeutic antibody discovery.

Funder

Ministry of Education - Singapore

Agency for Science, Technology and Research

National Medical Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/LC/D2LC00018K

Reference37 articles.

1. Antibody responses to viral infections: a structural perspective across three different enveloped viruses

2. Neutralizing antibody titers against dengue virus correlate with protection from symptomatic infection in a longitudinal cohort

3. Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection

4. Respiratory Syncytial Virus (RSV) Neutralizing Antibodies at Birth Predict Protection from RSV Illness in Infants in the First 3 Months of Life

5. The Human Antibody Response to Dengue Virus Infection

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