Stereoselective strain-release Ferrier rearrangement: the dual role of catalysts

Author:

Zhang Huajun1,Guo Aoxin1,Ding Han1ORCID,Xu Yuan1ORCID,Zhang Yuhan1,Yang Dan1,Liu Xue-Wei1ORCID

Affiliation:

1. School of Chemistry, Chemical Engineering and Biotechnology, 21 Nanyang Link, 637371 Singapore

Abstract

ACu(OTf)2/Fe(OTf)3-promoted facile and stereoselective synthesis of 2,3-unsaturated glycosides through Ferrier rearrangement of rationally designed glycals with C3-CCBz. The dual roles of the metal catalysts in the reaction are explored with DFT.

Funder

Nanyang Technological University

Ministry of Education - Singapore

National Research Foundation Singapore

Publisher

Royal Society of Chemistry (RSC)

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