Anticancer approach by targeted activation of a global inhibitor of sialyltransferases with acrolein-Reference-Cited by-同舟云学术

Anticancer approach by targeted activation of a global inhibitor of sialyltransferases with acrolein

Published:2024 Issue:25 Volume:15 Page:9566-9573
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Kasahara Takatsugu¹,Chang Tsung-Che¹²,Yoshioka Hiromasa²^ORCID,Urano Sayaka²,Egawa Yasuko²,Inoue Michiko³,Tahara Tsuyoshi⁴,Morimoto Koji²,Pradipta Ambara R.¹^ORCID,Tanaka Katsunori¹²^ORCID

Affiliation:

1. Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo, 152-8552, Japan

2. Biofunctional Synthetic Chemistry Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan

3. Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics Research, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan

4. Department of In vivo Imaging, Advanced Research Promoting Center, Tokushima University, 3-18-15 Kuramto-cho, Tokushima, Tokushima 770-8503, Japan

Abstract

Chemical regulation of glycan synthesis at the targeted cancer cell surface in mice leading to significant anticancer effects without side effects.

Funder

Japan Society for the Promotion of Science

Naito Foundation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC00969J

Reference33 articles.

1. Glycosylation in health and disease

2. Aberrant Sialylation in Cancer: Biomarker and Potential Target for Therapeutic Intervention?

3. Specific inhibition of human natural killer cell-mediated cytotoxicity by sialic acid and sialo-oligosaccharides

4. Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion

5. Modulation of Immune Tolerance via Siglec-Sialic Acid Interactions

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