Life cycle assessment of multi-step rufinamide synthesis – from isolated reactions in batch to continuous microreactor networks-Reference-Cited by-同舟云学术

Life cycle assessment of multi-step rufinamide synthesis – from isolated reactions in batch to continuous microreactor networks

Published:2016 Issue:4 Volume:18 Page:1096-1116
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Ott Denise¹²³⁴⁵,Borukhova Svetlana¹²³⁴⁵,Hessel Volker¹²³⁴⁵

Affiliation:

1. Laboratory of Chemical Reactor Engineering/Micro Flow Chemistry and Process Technology

2. Department of Chemical Engineering and Chemistry

3. Eindhoven University of Technology

4. 5600 MB Eindhoven

5. The Netherlands

Abstract

Rufinamide is an antiepileptic drug to treat Lennox–Gastaut syndrome, in combination with other medications. Herein, several batch and continuous process routes to rufinamide are analysed and optimised regarding their environmental impact, to finally predict a fully continuous, telescoped process route.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/GC/C5GC01932J

Reference121 articles.

1. P. T. Anastas and J. C.Warner, Green Chemistry: Theory and Practice, Oxford University Press, Oxford, UK, 1998

2. Peer Reviewed: Design Through the 12 Principles of Green Engineering

3. Life Cycle Assessment: Past, Present, and Future

4. The Continuous-Flow Synthesis of Ibuprofen

Cited by 71 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. How sustainability can get a competitive advantage: State of the Art for stationary battery storage systems;Cleaner Chemical Engineering;2024-09

2. Twenty-first century antiepileptic drugs. An overview of their targets and synthetic approaches;European Journal of Medicinal Chemistry;2024-06

3. Can biotechnology lead the way toward a sustainable pharmaceutical industry?;Current Opinion in Biotechnology;2024-06

4. Sustainability of flow chemistry and microreaction technology;Green Chemistry;2024

5. Assessing the environmental impacts of flow and batch syntheses of hypercrosslinked polymers for low-pressure CO2 adsorption;Separation and Purification Technology;2024-01