X-Ray responsive nanoparticles with triggered release of nitrite, a precursor of reactive nitrogen species, for enhanced cancer radiosensitization
Author:
Affiliation:
1. Department of Radiation Oncology-Radiation Physics
2. Stanford University
3. Stanford
4. USA 94305
5. Department of Chemistry
Abstract
New strategy to enhance cancer radiotherapy: A novel gold nanosystem with surface-grafted nitroimidazole and cell nucleus-targeting peptide achieves the release of a RNS precursor, nitrite, by ionizing radiation. In vitro radiotherapy shows enhanced sensitivity of hypoxic cancer cells to X-ray radiation, presumably due to the generation of both reactive oxygen and nitrogen species.
Funder
Stanford University
Publisher
Royal Society of Chemistry (RSC)
Subject
General Materials Science
Link
http://pubs.rsc.org/en/content/articlepdf/2017/NR/C7NR04684G
Reference49 articles.
1. Cancer nanomedicine: progress, challenges and opportunities
2. Stimuli-responsive nanocarriers for drug delivery
3. Bioresponsive materials
4. Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery
5. multifunctional enzymes in cancer
Cited by 30 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. A REVIEW ON RECENT ADVANCES ON STIMULI BASED SMART NANOMATERIALS FOR DRUG DELIVERY AND BIOMEDICAL APPLICATION;International Journal of Applied Pharmaceutics;2023-09-07
2. Application of nano‐radiosensitizers in combination cancer therapy;Bioengineering & Translational Medicine;2023-02-10
3. Orthogonal light-triggered multiple effects based on photochromic nanoparticles for DNA cleavage and beyond;Journal of Materials Chemistry B;2023
4. Recent progress in nitric oxide-generating nanomedicine for cancer therapy;Journal of Controlled Release;2022-12
5. An overview of the intracellular localization of high-Z nanoradiosensitizers;Progress in Biophysics and Molecular Biology;2022-11
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3