Genome mining of cryptic tetronate natural products from a PKS-NRPS encoding gene cluster in Trichoderma harzianum t-22-Reference-Cited by-同舟云学术

Genome mining of cryptic tetronate natural products from a PKS-NRPS encoding gene cluster in Trichoderma harzianum t-22

Published:2021 Issue:9 Volume:19 Page:1985-1990
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Zhu Yiguang¹²³⁴⁵^ORCID,Wang Junfeng¹²³⁴⁵^ORCID,Mou Pengyun⁴⁵⁶⁷⁸,Yan Yan¹²³⁴⁵^ORCID,Chen Mengbin¹²³,Tang Yi¹²³^ORCID

Affiliation:

1. Department of Chemical and Biomolecular Engineering

2. University of California Los Angeles

3. USA

4. Key Laboratory of Tropical Marine Bio-resources and Ecology

5. Guangdong Key Laboratory of Marine Materia Medica

6. South China Sea Institute of Oceanology

7. Chinese Academy of Sciences

8. Guangzhou 510301

Abstract

The gene cluster of trihazones was identified from Trichoderma harzianum t-22 and heterologously activated in Aspergillus nidualns. The α-KG dependent dioxygenase ThnC was confirmed to catalyze exocyclic double bond formation.

Funder

National Institute of Food and Agriculture

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D0OB02545C

Reference21 articles.

1. Molecular Diversity Sculpted by Fungal PKS-NRPS Hybrids

2. Biosynthesis of natural products by microbial iterative hybrid PKS–NRPS

3. H. Li , T. J.Booth and Y.-H.Chooi , in Comprehensive Natural Products III , ed. H.-W. Liu and T. P. Begley , Elsevier , Oxford , 2020 , pp. 415–444

4. Identification of the pyranonigrin A biosynthetic gene cluster by genome mining in Penicillium thymicola IBT 5891

5. Predicting the chemical space of fungal polyketides by phylogeny-based bioinformatics analysis of polyketide synthase-nonribosomal peptide synthetase and its modification enzymes

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