Membrane-active antimicrobial poly(amino-modified alkyl) β-cyclodextrins synthesized via click reactions

Author:

Yamamura Hatsuo12345ORCID,Nonaka Miho62345,Okuno Shingo62345,Mitsuhashi Ryogo62345,Kato Hisato7895ORCID,Katsu Takashi7895,Masuda Kazufumi10895,Tanimoto Koichi111213145,Tomita Haruyoshi151213145,Miyagawa Atsushi12345

Affiliation:

1. Life and Applied Chemistry

2. Graduate School of Engineering

3. Nagoya Institute of Technology

4. Nagoya 466-8555

5. Japan

6. Materials Science and Engineering

7. School of Pharmacy

8. Shujitsu University

9. Okayama 703-8516

10. Graduate School of Clinical Pharmacy

11. Laboratory of Bacterial Drug Resistance

12. Graduate School of Medicine

13. Gunma University

14. Maebashi

15. Department of Bacteriology and Laboratory of Bacterial Drug Resistance

Abstract

The modified cyclodextrins exhibited antimicrobial activity against drug-resistant bacteria and less hemolytic activity.

Funder

Adaptable and Seamless Technology Transfer Program through Target-Driven R and D

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Reference30 articles.

1. J. O'Neill , Review on Antimicrobial Resistance, Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations , supported by the Wellcome Trust and HM Government, 2014

2. European Centre for Disease Prevention and Control , Antimicrobial resistance surveillance in Europe 2015 , Annual report of the European Antimicrobial Resistance Surveillance Network (EARS-Net), 2017

3. Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review

4. Antimicrobial peptides of multicellular organisms

5. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies

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