A facile synthesis of sialylated oligolactosamine glycans from lactose via the Lafont intermediate-Reference-Cited by-同舟云学术

A facile synthesis of sialylated oligolactosamine glycans from lactose via the Lafont intermediate

Published:2014 Issue:9 Volume:5 Page:3634-3639
ISSN:2041-6520
Container-title:Chem. Sci.
language:en
Short-container-title:Chem. Sci.

Author:

Peng Peng¹²³,Liu Han¹²³,Gong Jianzhi¹²³,Nicholls John M.⁴⁵²³,Li Xuechen¹²³⁶²

Affiliation:

1. Department of Chemistry

2. The University of Hong Kong

3. Hong Kong

4. Department of Pathology

5. Li Ka-Shing Faculty of Medicine

6. The State Key Laboratory of Synthetic Chemistry

Abstract

We have developed a facile synthesis of sialylated oligolactosamine glycans, including Neu5Ac-α-2,3LacNAc-β-1,3LacNAc (3′SLN-LN) and Neu5Ac-α-2,3LacNAc-β-1,3LacNAc-β-1,3LacNAc (3′SLN-LN-LN), also providing a useful method for the preparation of 2-amino sugar building blocks.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/SC/C4SC01013B

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