Microchip-based structure determination of low-molecular weight proteins using cryo-electron microscopy-Reference-Cited by-同舟云学术

Microchip-based structure determination of low-molecular weight proteins using cryo-electron microscopy

Published:2021 Issue:15 Volume:13 Page:7285-7293
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Casasanta Michael A.¹²³⁴⁵,Jonaid G. M.¹²³⁴⁶,Kaylor Liam¹²³⁴⁷,Luqiu William Y.⁵²³⁴⁸,Solares Maria J.¹²³⁴⁷,Schroen Mariah L.⁵²³⁴,Dearnaley William J.¹²³⁴⁵,Wilson Jarad⁹¹⁰⁴,Dukes Madeline J.¹¹¹²¹³¹⁴⁴,Kelly Deborah F.¹²³⁴⁵^ORCID

Affiliation:

1. Department of Biomedical Engineering

2. Pennsylvania State University

3. University Park

4. USA

5. Materials Research Institute

6. Bioinformatics and Genomics Graduate Program

7. Molecular

8. Department of Electrical and Computer Engineering

9. RayBiotech Life

10. Peachtree Corners

11. Applications Science

12. Protochips

13. Inc

14. Morrisville

Abstract

Here we show a major technical advance to study small proteins using cryo-EM. Structural models for the SARS-CoV-2 Nucleocapsid (N) protein are presented along with other coronavirus counterparts for therapeutic development.

Funder

Huck Institutes of the Life Sciences

National Institutes of Health

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NR/D1NR00388G

Reference50 articles.

1. Silicon nitride windows for electron microscopy of whole cells