Building <i>Streptomyces albus</i> as a chassis for synthesis of bacterial terpenoids-Reference-Cited by-同舟云学术

Building Streptomyces albus as a chassis for synthesis of bacterial terpenoids

Published:2023 Issue:13 Volume:14 Page:3661-3667
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Hu Yi Ling¹,Zhang Qi¹,Liu Shuang He¹,Sun Jia Li¹,Yin Fang Zhou¹,Wang Zi Ru¹,Shi Jing¹,Jiao Rui Hua¹,Ge Hui Ming¹^ORCID

Affiliation:

1. State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Chemistry and Biomedicine Innovation Centre (ChemBIC), School of Life Sciences, Nanjing University, Nanjing, 210023 China

Abstract

We built a Streptomyces expression system to discovery bacterial terpenoids. Though genome mining and expression of terpene BGCs, 11 terpene skeletons including 3 new ones, and 18 novel distinct terpenoids were isolated and characterized.

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D2SC06033G

Reference45 articles.

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2. Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases